In vitro studies have demonstrated that itraconazole impairs the synthesis of ergosterol in fungal cells. Ergosterol is a vital cell membrane component in fungi. Impairment of its synthesis ultimately results in an antifungal effect.For itraconazole, breakpoints have only been established for Candidaspp. from superficial mycotic infections (CLSI M27-A2, breakpoints have not been established for EUCAST methodology).
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