Febuxostat has been shown to potently inhibit both the oxidized and reduced forms of XO. At therapeutic concentrations, Febuxostat does not inhibit other enzymes involved in purine or pyrimidine metabolism, namely, guanine deaminase, hypoxanthine guanine phosphoribosyl transferase, orotate phosphoribosyl transferase, orotidine monophosphate decarboxylase or purine nucleoside phosphorylase.
Info Sheet