Methyl Salicylate is a salicylic acid derivative that is irritant to the skin and is used topically in rubefacient preparations for the relief of pain in musculoskeletal, joint and soft tissue disorders.
When applied to the skin, Menthol dilates blood vessels, causing a sensation of coldness followed by an analgesic effect.
Capsicum Oleoresin provides relief via localized depletion of substance P, a neuropeptide involved in the transmission of pain impulses from the periphery to the central nervous system.
Methyl Salicylate may be absorbed through intact skin. Methyl Salicylate is extensively metabolised to salicylic acid in the dermal and subcutaneous tissues after topical application.
After absorption, Menthol is excreted in urine and bile as glucoronide.
Metabolism of capsicum and other capsaicinoids by cytochrome P450 enzymes in the skin is minimal. However absorbed capsicum is metabolised to 16-hydroxy capsaicin, 17-hydroxy capsaicin and 16,17 dehydrocapsaicin.