Cosmos Pharmaceutical Limited | PANORUB®Cream
Cosmos Limited is one of the leading manufacturers of pharmaceutical products in Kenya and East Africa. Through our specialized Human Health and Animal Health.
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PANORUB®Cream

CLINICAL PHARMACOLOGY:

Methyl Salicylate is a salicylic acid derivative that is irritant to the skin and is used topically in rubefacient preparations for the relief of pain in musculoskeletal, joint and soft tissue disorders.
When applied to the skin, Menthol dilates blood vessels, causing a sensation of coldness followed by an analgesic effect.
Capsicum Oleoresin provides relief via localized depletion of substance P, a neuropeptide involved in the transmission of pain impulses from the periphery to the central nervous system.

Pharmacokinetics:

Methyl Salicylate may be absorbed through intact skin. Methyl Salicylate is extensively metabolised to salicylic acid in the dermal and subcutaneous tissues after topical application.
After absorption, Menthol is excreted in urine and bile as glucoronide.
Capsicum Oleoresin
Metabolism of capsicum and other capsaicinoids by cytochrome P450 enzymes in the skin is minimal. However absorbed capsicum is metabolised to 16-hydroxy capsaicin, 17-hydroxy capsaicin and 16,17 dehydrocapsaicin.

USES:

It is used for symptomatic relief of muscular pain, rheumatic pain, lumbago, sciatica and other pain from stiffness, sprains, bruises and cramps.

It contains:

  • – Methyl Salicylate BP      10%
  • – Menthol BP    5.0%
  • – Capsicum Oleoresin     0.1%

DOSAGE  AND  ADMINISTRATION:

Apply and massage gently to the affected part until it is completley absorbed into the skin. Repeat two or three times a day.

FOR EXTERNAL USE ONLY

CONTRA-INDICATIONS AND  WARNINGS:
Precautions:

Do not apply to broken skin or near the eyes or nose. Discontinue use if excessive irritation occurs. Wash hands thoroughly after use. Not to be used on children under the age of 5 years.

Adverse Effects:

Menthyl salicylate: Rarely salicylate intoxication can occur following topical application of methylsalicylate.
Menthol: Menthol may give rise to hypersensitivity reactions including contact dermatitis.
Capsicum Oleoresin: Mild irritation, redness or burning sensation at the site of application. Rarely allergic reactions or severe skin irritation.

PHARMACEUTICAL   PRECAUTIONS:

Store in a dry place below 25°C. Protect from light.  Keep all medicines out of the reach of children.

LEGAL CATEGORY:
Over The Counter (OTC)
General Sale List (GSL)
®Regd TM          Ref. No.: INS290/06.08

IMAGES
  • PANORUB®Cream

    PresentationClean, white to off white, smooth, homogeneous cream, free from visible evidence of contamination with characteristic odour.Pack size -15g & 45g