Cosmos Pharmaceutical Limited | MULTIMOS®
Cosmos Limited is one of the leading manufacturers of pharmaceutical products in Kenya and East Africa. Through our specialized Human Health and Animal Health.
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MULTIMOS®

CLINICAL  PHARMACOLOGY:

Vitamin A, a fat-soluble vitamin, is essential for growth, for the development and maintenance of epithelial tissue, and for vision, particularly in dim light.
Vitamin D3 (colecalciferol) compounds are fat-soluble sterols, which are essential for the proper regulation of calcium and phosphate homoeostasis and bone mineralisation.
Thiamine (Vitamin B1), a water-soluble vitamin, is an essential coenzyme for carbohydrate metabolism. Thiamine is used in the treatment and prevention of thiamine deficiency.
Riboflavin (Vitamin B2), a water-soluble vitamin, is essential for the utilisation of energy from food. The active, phosphorylated forms, flavine mononucleotide (FMN) and flavine adenine dinucleotide (FAD), are involved as coenzymes in oxidative/reductive metabolic reactions. Riboflavin is also necessary for the functioning of pyridoxine and nicotinic acid.
Nicotinic acid and nicotinamide (Vitamin B3), are water-soluble vitamin B substances which are converted to nicotinamide adenine dinucleotide and  nicotinamide adenine dinucleotide phosphate (NADP). These coenzymes are involved in electron transfer reactions in the respiratory chain.
Ascorbic Acid (Vitamin C), a water-soluble vitamin, is essential for the synthesis of callogen and intercellular material.

Pharmacokinetics:

Vitamin A is readily absorbed from the gastrointestinal tract. Vitamin A esters are hydrolysed by pancreatic enzymes to retinol which is then absorbed and re-esterified. Some retinol is stored in the liver. It is released from the liver bound to a specific a1-globulin (retinol-binding protein) in the blood. The retinol not stored in the liver undergoes glucuronide conjugation and subsequent oxidation to retinal and retinoic acid; these and other metabolites are excreted in urine and faeces.
Vitamin D substances are well absorbed from the gastrointestinal tract. The presence of bile is essential for adequate intestinal absorption; absorption may be decreased in patients with decreased fat absorption. Vitamin D compounds and their metabolites are excreted mainly in the bile and faeces with small amounts appearing in urine; there is some enterohepatic recycling but it is considered to have a negligible contribution to Vitamin D status. Certain vitamin D substances may be distributed into breast milk.

MULTIMOS®  TABLETS

Small amounts of thiamine are well absorbed from the gastrointestinal tract following oral administration, but the absorption of doses larger than about 5 mg is limited. It is widely distributed to most body tissues, and appears in breast milk. Thiamine is not stored to any appreciable extent  in the body and amounts in excess of the body’s requirements are excreted in the urine as unchanged thiamine or as metabolites.
Riboflavin (Vitamin B2) is readily absorbed from the gastrointestinal tract. Although riboflavin is widely distributed to body tissues little is stored in the body. Riboflavin is converted in the body to the coenzyme flavine mononucleotide (FMN; riboflavin 5′-phosphate) and then to another coenzyme flavine adenine dinucleotide (FAD). About 60% of FMN and FAD are bound to plasma proteins. Riboflavin is excreted in urine, partly as metabolites. As the dose increases, larger amounts are excreted unchanged. Riboflavin crosses the placenta and is distributed in breast milk.
Nicotinamide (Vitamin B3) is readily absorbed from the gastrointestinal tract following oral administration and widely distributed in the body tissues. Small amounts of Nicotinamide is excreted unchanged in the urine.
Ascorbic acid is readily absorbed from the gastrointestinal tract and is widely distributed in the body tissues.
Ascorbic acid in excess of the body’s needs is also rapidly eliminated unchanged in the urine. Ascorbic acid crosses the placenta and is distributed into breast milk

Each film coated tablet contains:

  • Vitamin A             2500 iu
  • Vitamin D3             300 iu
  • Thiamine mononitrate         (Thiamine Nitrate BP)1.0mg
  • Riboflavin BP                0.5mg
  • Nicotinamide BP         7.5mg
  • Ascorbic Acid BP (coated)    15mg

USES:

Multimos tablets are essential food requirements for good health and provide:
– Resistance to fight infections.
– Protection from vitamin insufficiency.
– Faster recovery in ill health.
Multimos tablets are used for prevention of vitamin deficiency.

DOSAGE   AND   ADMINISTRATION:

Adults: 2 to 3 tablets daily.
Children: 5 years and above: 1 tablet daily.

CONTRA-INDICATIONS  AND  WARNINGS:

Excessive use of Vitamin A  should be avoided in pregnancy. Vitamin D should be administered with caution to infants as they may have increased sensitivity to its effects.

Adverse Effects:

The administration of excessive amount of Vitamin A over  long periods can lead to toxicity  known as hypervitaminosis A. This is characterised by fatigue, irritability, anorexia and loss of weight, vomiting and other gastro-intestinal tract disturbances, low grade fever, hepatosplenomegaly, skin changes, alopecia, dry hair, cracking and bleeding lips, anaemia, headache, hypercalcaemia, subcutaneous swelling and pains in bones and joints. Excessive amounts of calcium salts may lead to hypercalcaemia.

PHARMACEUTICAL   PRECAUTIONS:

Store in a dry place below 25°C. Protect from light. Keep all medicines out of the reach of children.

LEGAL   CATEGORY:
Over The Counter (OTC)
General Sales List (GSL)
®Regd. TM                       Ref. No. INS222/03.10

IMAGES
  • MULTIMOS®Tablets F/C (Multivitamin)

    Presentation

    Multimos Tablets (Film Coated): Red, circular, biconvex, film coated tablet plain on both sides.
    Each film coated tablet contains:
    Pack size -100's (10x10's)