Cosmos Pharmaceutical Limited | LORHISTINA®
Cosmos Limited is one of the leading manufacturers of pharmaceutical products in Kenya and East Africa. Through our specialized Human Health and Animal Health.
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LORHISTINA®

CLINICAL PHARMACOLOGY:

Loratadine, a piperidine derivative related to azatadine, is a long-acting, non-sedating antihistamine with no significant antimuscarinic activity.
Pharmacokinetics:
Loratadine is rapidly absorbed from the gastro-intestinal tract after oral administration, peak plasma concentrations being attained in about one hour. Bioavailability is increased and time to peak plasma concentrations is delayed when administered with food. Loratadine undergoes extensive metabolism. The major metabolite, descarboethoxyloratadine (desloratadine), has potent antihistaminic activity. Reported mean elimination half-lives for Loratadine and descarboethoxyloratadine are 8.4 and 28 hours respectively. Loratadine is about 98% bound to plasma proteins; descarboethoxyloratadine is less extensively bound. Loratadine and its metabolites have been detected in the breast milk, but do not appear to cross the blood-brain barrier to a significant extent. Most of a dose is excreted equally in the urine and faeces, mainly in the form of metabolites.

LORHISTINA®

USES:

Lorhistina® is a histamine H1-receptor antagonist that does not generally cause sedation or antimuscarinic effect. It is given for symptomatic relief of allergic conditions including rhinitis and chronic urticaria.

DOSAGE  AND  ADMINISTRATION:

Adults including the elderly and Children 12 years of age and over:
10mg (one tablet) or two 5mL spoonfuls once daily.
Children aged 6 to 12 years: 10mg (one tablet) or two 5mL spoonfuls of syrup once daily.
Children aged 2 to 5 yrs: 5mg (one tablet) or one 5mL spoonful of syrup once daily.


CONTRA-INDICATIONS AND WARNINGS:

Drowsiness can occur and it may affect the performance of skilled tasks. Occasionally reports of convulsions in patients taking antihistamines also call for caution in patients with epilepsy. Caution is also needed in hepatic impairment. Antihistamines should not be given to neonates owing to the increased susceptability to antimuscarinic effects.

Adverse Effects:

Occasional gastro-intestinal adverse effects of antihistamines include nausea, vomiting, diarrhoea, or epigastric pain. Administration of antihistamines may sometimes cause rashes and hypersensitivity reaction and cross-sensitivity.
Other adverse effects with antihistamines include convulsions, sweating, myalgia, paraesthesias, extrapyramidal effects, tremor, sleep disturbances, depression, tinnitus, hypotension and hair loss.

Interactions:

Sedative interactions apply to non-sedating antihistamines: they do not appear to potentiate the effects of alcohol, but it should be avoided in excess. Antihistamines may suppress the cutaneous histamine response to allergen extracts and should be stopped several days before skin testing.

PHARMACEUTICAL PRECAUTIONS:

Store in a dry place below 25ºC. Protect  from light. Keep all medicines out of the reach of children.

LEGAL CATEGORY:
Prescription Only Medicine (POM)
®Regd. TM                                                          Ref. No. INS151/06.09

IMAGES
  • LORHISTINA®Tablets

    PresentationLorhistina® Tablets 10mg: White, circular biconvex tablet embossed 'COSMOS' on one side and a breakline on the other side. Each tablet contains: Loratadine USP 10mg..Pack size -30's (3x10's)

  • LORHISTINA®Syrup

    PresentationLorhistina® Syrup 5mg/5mL: Straw yellow coloured syrup slightly viscous free from visible evidence of contamination with raspberry odour. Each 5mL contains: Loratadine USP 5mg/5mL.Pack size - 60ml