Lipecos® 5 Tablets: Yellow, circular, biconvex film coated tablet embossed ‘C’ on one side and plain on the other side. Each film coated tablet contains: Rosuvastatin calcium equivalent to Rosuvastatin 5 mg, Lactose and other excipients. Lipecos® 10 Tablets: Salmon Red, circular, biconvex film coated tablet embossed ‘C’ on one side and plain on the other side. Each film coated tablet contains: Rosuvastatin calcium equivalent to Rosuvastatin 10 mg, Lactose and other excipients.
Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3- methylglutaryl coenzyme A to mevalonate, a precursor for cholesterol. The primary site of action for Rosuvastatin is the liver, the target organ for cholesterol lowering. Rosuvastatin increases the number of hepatic LDL receptors on the cell-surface, enhancing uptake and catabolism of LDL and it inhibits the hepatic synthesis of VLDL, thereby reducing the total number of VLDL and LDL particles.
Rosuvastatin is incompletely absorbed from the gastrointestinal tract, with a bioavailability of about 20%.Peak plasma concentrations are achieved about 5 hours after an oral dose. It is taken up extensively by the liver, its primary site of action, and undergoes limited metabolism, mainly by the cytochrome P450 isoenzyme CYP2C9. Approximately 90% of an oral dose of Rosuvastatin is excreted in the faeces, including absorbed and non-absorbed drug. The remainder is excreted in the urine, about 5% of the dose is excreted unchanged. USES Treatment of hypercholesterolemia Adults, adolescents and children aged 10 years or older with primary hypercholesterolemia (type IIa including heterozygous familial hypercholesterolemia) or mixed dyslipidemia (type IIb) as an adjunct to diet when response to diet and other non-pharmacological treatments (e.g. exercise, weight reduction) are inadequate. Prevention of cardiovascular events Prevention of major cardiovascular events in patients who are estimated to have a high risk for a first cardiovascular event, as an adjunct to correction of other risk factors.
DOSAGE AND ADMINISTRATION
Usual doses in adults Usual initial dose: 5 mg or 10 mg. The maximum daily dose of Rosuvastatin is 40 mg. In children and adolescents aged 10-17 years The usual starting dose is 5 mg. Your doctor may increase your dose to find the right amount of Rosuvastatin for you. The maximum daily dose of Rosuvastatin is 20 mg. The dose should be taken once a day.