Dextromethorphan Hydrobromide is a cough suppressant used for the relief of non-productive cough; it has a central action on the cough centre in the medulla.
Triprolidine Hydrochloride, an alkylamine derivative, is a sedating antihistamine with antimuscarinic and mild sedative effects.
Phenylephrine hydrochloride is a sympathomimetic amine which acts on alpha adrenergic receptors or the respiratory tract to produce vasoconstriction, which temporarily reduces the swelling associated with inflammation of the mucous membranes lining the nasal and sinus passages. This allows the free drainage of the sinusoidal fluid from the sinuses. It also supresses the production of mucus, therefore preventing a build up of fluid within the cavities.
Ibuprofen, a propionic acid derivative, is an NSAID used in the management of mild to moderate pain and fever.
‘Ascorbic Acid (coated) Vitamin C’, a water-soluble vitamin, is essential for the synthesis of collagen and intercellular material.
Dextromethorphan is rapidly absorbed from the gastro-intestinal tract. It is metabolised in the liver and excreted as unchanged dextromethorphan and demethylated metabolites.
After absorption from the gastro-intestinal tract, Triprolidine is metabolised; a carboxylated derivative accounts for about half the dose excreted in the urine. Reported half-lives vary from 3-5 hours or more.
Phenylephrine Hydrochloride is readily absorbed after oral administration but is subject to extensive presystemic metabolism. It has a mean plasma half-life in the range of 2-3 hours.Following absorption, the drug is extensively biotransformed in the liver and both phenylephrine hydrochloride and its metabolites are excreted in urine. It is excreted in breast milk, but no harm should come to neonate if intake is not excessive.