Cosmos Pharmaceutical Limited | DABORAL®
Cosmos Limited is one of the leading manufacturers of pharmaceutical products in Kenya and East Africa. Through our specialized Human Health and Animal Health.
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Aminosidine Sulphate (paromomycin) is an aminoglycoside antibiotic. Aminosidine has  a broad spectrum of activity, including activity against protozoa especially Entamoeba histolytica, bacteria and cestodes. The drug is believed to act against both the trophozoite and encysted forms of Entamoeba. Aminosidine has an antibacterial spectrum similar to that of neomycin. Aminosidine is active against some gram-positive bacteria (e.g. some strains of Staphylococcus) and many gram-negative aerobic bacteria, but generally is inactive against Pseudomonas aeruginosa and anaerobic bacteria. Aminosidine also has some activity against Mycobacterium tuberculosis. Aminosidine has been shown to be active against certain cestodes (tapeworms) pathogenic to humans including Diphyllobothrium latum (fish tapeworm), Taenia saginata (beef tapeworm), and T.solium (pork tapeworm).


Aminosidine is poorly absorbed from the gastro-intestinal tract and most of the dose is eliminated unchanged in the faeces.


Daboral® is used in the treatment of intestinal protozoal infections, including amoebiasis, cryptosporidiosis, and giardiasis. It has been used in the treatment of tapeworm infection. Also in the suppression of intestinal flora both pre-operatively and in the management of hepatic encephalopathy.

Prophylactic treatment of hepatic coma:

Adults: 2g daily for 6 days.
Children: 50mg/kg/day for 6 days

Daboral® is administered orally, with or after meals, in 2-4 divided doses. The physician can also adjust the dosages and duration of treatment according to the severity and duration of the diseases.


Amoebiasis, Giardiasis (Lambliasis) and Balantidiasis:
Adults: 500mg twice a day for 5-7 days.
Children: 30mg/kg/day in two divided doses for 5-7 days.
Cryptosporidiosis: Adults: 500mg four times a day for 14 days.
Gastro-enteritis and enterocolitis due to mixed flora, salmonellosis and shigellosis:
Adults: 500mg twice a day for 5-7 days.
Children: 30mg/kg/day in two divided doses for 5-7 days.
Prophylactic sterilization in gastro-intestinal surgery:
Adults: 2g daily for 3 days.
Children: 50mg/kg/day for 3 days.

The use of Aminosidine may result in the overgrowth of nonsusceptible organisms, especially Candida, and patients should be carefully monitored for the development of new infections caused by nonsusceptible organisms. Secondary  Staphylococcus enterocolitis may occur. Aminosidine should be administered with caution to patients with ulcerative intestinal lesions to avoid renal toxicity through inadvertent absorption of the drug. High doses or prolonged therapy with Aminosidine should be avoided. Since Aminosidine is only active against intestinal protozoa, the drug should not be used in the treatment of extraintestinal amoebiasis. Aminosidine is contraindicated in patients with intestinal obstruction and in patients with a known hypersensitivity to the drug.
Adverse Effects:
They include anorexia, nausea, vomiting, epigastric burning and pain, increased gastro-intestinal motility, abdominal cramps, diarrhoea, and pruritus ani. Aminosidine has also been reported to cause hypocholesterolemic and malabsorptive effects. Malabsorption of xylose, sucrose and abnormal fat metabolism have been demonstrated. Aminosidine may also cause steatorrhea by precipitation of bile salts. Other adverse effects reported following oral administration of Aminosidine include rash, headache, vertigo, eosinophilia, exanthema, and unexplained hematuria.
Aminosidine has been reported to impair the absorption of other drugs including phenoxymethylpenicillin, digoxin and methotrexate; the efficacy of oral contraceptives might be reduced. The effects of acarbose may be enhanced.


Store in a dry place below 25ºC. Protect  from light. Keep all medicines out of the reach of children.

Prescription Only Medicine (POM)
®Regd. TM                                         Ref. No.: INS252/09.08

  • DABORAL®250 Tablets

    PresentationWhite, circular flat bevelled edge tablet with a breakline on one side and plain on the other side. Each tablet contains: Aminosidine Sulphate equivalent to Aminosidine Base 250mg. Pack size - 20's (2x10's)

  • DABORAL®Syrup

    PresentationPale yellow solution free from visible evidence of contamination with pleasant taste. Each 5mL contains: Aminosidine Sulphate equivalent to Aminosidine Base 125mg. Pack size - 60ml