Cosmos Pharmaceutical Limited | COSMOL®
Cosmos Limited is one of the leading manufacturers of pharmaceutical products in Kenya and East Africa. Through our specialized Human Health and Animal Health.
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COSMOL®

CLINICAL PHARMACOLOGY:
Paracetamol, a para-aminophenol derivative, has analgesic, antipyretic and weak anti-inflammatory activity.  Paracetamol  selectively inhibits cyclo-oxygenase  enzyme in the brain and spinal cord thus reliefing pain and reducing fever without having unwanted gastro intestinal side effects. Paracetamol interfers with nerve conduction and is known to block impulse generations  at bradykinin-sensitive chemoreceptors which evoke pain.
Pharmacokinetics:
Paracetamol is readily absorbed from the gastro-intestinal tract with peak plasma concentrations occurring about 10 to 60 minutes after oral doses. Paracetamol is distributed into most body tissues. It crosses the placenta and is present in breast milk. Plasma protein binding is negligible at usual therapeutic concentrations but increases with increasing concentrations. The elimination half-life of paracetamol varies from about 1 – 3 hours. Paracetamol is metabolised predominantly in the liver and excreted in the urine mainly as the glucuronide and sulfate conjugates.

USES:
COSMOL®  preparations are recommended for the treatment of most painful and febrile conditions. It relieves headache, backache, toothache, rheumatic, muscle and period pains. COSMOL®  helps relieve pain and fever in colds, influenza, sore throat also high body temperature and mild pain due to non-serious arthritis.
COSMOL® is recommended for the treatment of painful and febrile conditions of childhood such as teething, headache, toothache, earache, general aches and pains, colds, influenza and reactions after immunization and vaccination.

DOSAGE  AND  ADMINISTRATION:
Doses to be given 3-4 times a day or as directed by the physician.

Cosmol® Suspension 120mg/5mL:

Children: 6 – 12 years: Half-one tablet or two-four spoonfuls (10-20mL).

1 – 6 years: One – two spoonfuls (5.0-10mL).
3 months – 1 year: Half – one spoonful (2.5-5mL).
Under 3 months: Not recommended.

COSMOL®
Adults and Children over 12 years:
Cosmol Tablets 500mg:
One – two tablets 3-4 times a day.
Do not take more than 8 tablets in 24 hours.

Children should not be given doses of COSMOL® Suspension more frequently than every 4 hours and not more than 4 doses should be given in any 24 hour period.

CONTRA-INDICATIONS  AND  WARNINGS:

Precautions:
Paracetamol should be given with care to patients with impaired kidney or liver function. It should also be given with care to patients with alcohol dependence.

Adverse Effects:
Adverse effects of Paracetamol are rare and usually mild, although haematological reactions including thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Skin rashes, and other hypersensitivity reactions occur occasionally.

Overdosage:

  • Overdosage with Paracetamol can result in severe liver damage and sometimes acute renal tubular necrosis.
  • Gastric lavage should be carried out especially if the overdose was taken within the previous hours; full supportive measures should also be instituted.
  • Activated charcoal is given to reduce gastro-intestinal absorption, especially in cases of multiple drug overdosage. However, if acetylcysteine or methionine is to be administered by mouth, the charcoal is best cleared from the stomach to prevent it reducing the absorption of the antidote.

Interactions:
The risk of Paracetamol toxicity may be increased in patients receiving other potentially hepatotoxic drugs or drugs that induce liver microsomal enzymes. The absorption of paracetamol may be accelerated by drugs such as metoclopramide. Excretion may be affected and plasma concentrations altered when given with probenecid.

PHARMACEUTICAL PRECAUTIONS:
Store in a dry place below 25ºC.  Protect from light.  Keep all medicines out of the  reach of children.

LEGAL CATEGORY:
Over The Counter (OTC)
General Sales List (GSL)
®Regd. TM Ref. No. INS013/04.08

IMAGES
  • COSMOL® Suspension 120mg/5mL

    Presentation Clean, light pink, viscous suspension free from visible evidence of contamination with fruity odour. Each 5mL contains: Paracetamol BP 120mg..Pack size - 60mL & 100mL

  • COSMOL® Tablets 500mg

    Presentation White, circular, flat, bevelled-edge tablet embossed 'COSMOL' on one side and P 500 with a breakline on the other side. Each tablet contains: Paracetamol BP 500mg.Pack size - 100's (10x10's)