Cosmos Pharmaceutical Limited | COPAZINE®
Cosmos Limited is one of the leading manufacturers of pharmaceutical products in Kenya and East Africa. Through our specialized Human Health and Animal Health.
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COPAZINE®

CLINICAL  PHARMACOLOGY:

Cetirizine Hydrochloride, a piperazine derivative and metabolite of hydroxyzine, is described as a non-sedating antihistamine which is long-acting and has some mast-cell stabilising activity. It appears to have a low potential for drowsiness in usual doses and to be virtually free of antimuscarinic activity.

Pharmacokinetics

Cetirizine is rapidly absorbed from the gastrointestinal tract after oral administration, peak plasma concentrations being attained within about one hour. Food delays the time to peak plasma concentrations but does not decrease the amount of drug absorbed. It is highly bound to plasma proteins and has an elimination half-life of about 10 hours. Cetirizine has been detected in breast milk. Cetirizine is excreted primarily in the urine mainly as unchanged drug. Cetirizine does not appear to cross the blood-brain barrier to a significant extent.

USES:

It is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria.

COPAZINE®

DOSAGE  AND  ADMINISTRATION:

In adults and children aged 6 years and over, Cetirizine Hydrochloride is given by mouth in a dose of 10 mg once daily or 5 mg twice daily. Children aged 2 to 5 years may be given Cetirizine 5 mg once daily or 2.5 mg twice daily. Children aged 6 months to 2 years may be given a dose of 2.5 mg once daily, increased to a maximum of 2.5 mg twice daily in those aged 12 months and over, for the treatment of perennial allergic rhinitis and chronic urticaria.


CONTRA-INDICATIONS AND  WARNINGS:
Precautions:

Dosage of Cetirizine should be reduced in patients with hepatic or renal impairment

Adverse Effects:

Occasional gastrointestinal side-effects of antihistamines include nausea, vomiting, diarrhoea, or epigastric pain. Those with antiserotonin actions, such as cyproheptadine, may cause an increase in appetite with resultant weight gain, whereas anorexia has been reported with some other antihistamines.

Interactions:

As for the non-sedating antihistamines in general,  However, some interactions are less likely with cetirizine than with non-sedating antihistamines such as astemizole and terfenadine, since cetirizine appears to have low hepatic metabolism and little arrhythmogenic potential.

PHARMACEUTICAL  PRECAUTIONS:

Store in a dry place below 25°C, Protect from light. Keep all medicines out of the reach of children.

LEGAL  CATEGORY:
Prescription Only Medicine (POM)
®Regd. TM  Ref. No. INS264/03.06

IMAGES
  • COPAZINE®Tablets F/C

    PresentationWhite, circular, biconvex, film coated tablet embosed 'COSMOS' on one side and a breakline on the other side. Each film coated tablet contains: Cetirizine Hydrochloride 10mg. Pack size - 30's (3x10's)

  • COPAZINE®Oral Solution

    PresentationClear liquid free from visible evidence of contamination with fruity odour. Each 5mL contains: Cetirizine Hydrochloride 5mg. Pack size - 60mL