Cosmos Pharmaceutical Limited | CLARICOS®
Cosmos Limited is one of the leading manufacturers of pharmaceutical products in Kenya and East Africa. Through our specialized Human Health and Animal Health.
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Clarithromycin is a macrolide antibacterial with a broad and essentially bacteriostatic action against many Gram-positive and to a lesser extent some Gram-negative bacteria, as well as other organisms including some Mycoplasma spp., Chlamydiaceae, Rickettsia spp., and spirochaetes. Clarithromycin and other macrolides bind reversibly to the 50S subunit of the ribosome, resulting in blockage of the transpeptidation or translocation reactions, inhibition of protein synthesis, and hence inhibition of cell growth. Because macrolides penetrate readily into white blood cells and macrophages there has been some interest in their potential synergy with host defence mechanisms in vivo.


Clarithromycin is rapidly absorbed from the gastro-intestinal tract following oral administration, and undergoes first-pass metabolism; the bioavailability of the parent drug is about 55%. The extent of absorption is relatively unaffected by the presence of food. Peak concentrations of Clarithromycin and its principal active metabolite 14-hydroxyclarithromycin are reported to be about 900 and 600 nanograms/mL respectively following a single 250mg dose by mouth; at steady state the same dose given every 12 hours as tablets produces peak concentrations of Clarithromycin of about 1microgram/mL. The drug and its principal metabolite are widely distributed, and tissue concentrations exceed those in serum, in part because of intracellular uptake. Clarithromycin has been detected in breast milk. It is extensively metabolised in the liver, and excreted in the faeces via the bile. The terminal half-life of Clarithromycin is reportedly about 3 to 4 hours in patients receiving 250mg doses twice daily, and about 5 to 7 hours in those receiving 500mg twice daily. The half-life is prolonged in renal impairment.


Claricos® is given in the treatment of respiratory-tract infections (including otitis media) and in skin and soft-tissue infections.
Clarithromycin is also used for the prophylaxis and treatment of opportunistic mycobacterial infections and has been used in the treatment of leprosy. Clarithromycin may be given to eradicate Helicobacter pylori in treatment regimens for peptic ulcer disease. It has been tried in protozoal infections, including toxoplasmosis.


Adults: 250mg twice daily by mouth, increased to 500mg twice daily if necessary in severe infection. A course is usually for 7 to 14 days.
Children: 7.5mg per kg body-weight twice daily for 5 to 10 days.
For disseminated infection due to Mycobacterium avium complex, 500mg twice daily by mouth, in conjuction with other antimycobacterials.
Leprosy: 500mg daily by mouth has been given as part of an alternative multidrug therapy regimen.
H.pylori associated with peptic ulcer disease: Claricos® is given in combination with a proton pump inhibitor or a histamine H2-receptor antagonist and sometimes also another antibacterial. Suggested regimes include either a 7 day triple therapy with Claricos® 250mg or 500mg twice daily plus Omeprazole e.g. (OMECOS®), or either a nitroimidazole or Amoxicillin e.g (CAMOX®), or a 14-day dual therapy with Claricos® 250mg four times daily.
For reconstitution instructions, refer to label / carton.


Clarithromycin should be avoided in those known to be hypersensitive to it, or in those who have previously developed liver disorders while receiving it. It should be used with care in patients with existing liver disease or hepatic impairment.

Adverse Effects:

Gastro-intestinal disturbances are the most frequent adverse effects but are usually mild and less frequent. Taste disturbances, stomatitis, glossitis, tooth discolouration and headache have occurred. There have also been reports of transcient CNS effects such as anxiety, dizziness, insomnia, hallucinations and confusion. Other adverse effects include hypoglycaemia, leucopenia, and thrombocytopenia.


Increased rifabutin toxicity has been reported in patients receiving Clarithromycin and rifabutin and there has been a report of delirium following concurrent use with fluoxetine.


Store in a dry place below 25ºC. Protect from light. Keep all medicines out of the reach of children.

Prescription Only Medicine (POM)
®Regd TM            Ref. No.: INS269/11.07

  • CLARICOS®250 Tablets

    PresentationYellow, capsule shaped, biconvex film coated tablet embossed '250' on one side and plain on the other side. Each film coated tablet contains: Clarithromycin USP 250mg. Pack size -14's (1x14's)

  • CLARICOS®500 Tablets

    PresentationYellow, capsule shaped, biconvex film coated tablet embossed '500' on one side and plain on the other side. Each film coated tablet contains: Clarithromycin USP 500mg. Pack size - 14's (1x14's)

  • CLARICOS®125 Dry Powder for Susp.

    PresentationWhite to off white granules which when reconstituted forms a white to off white suspension containing white suspended particles with a fruity flavour. Each 5mL spoonful of the resultant suspension contains: Clarithromycin USP 125mg. Pack size - 70ml