Aspirin has analgesic, anti-inflammatory and antipyretic properties; it acts as an inhibitor of the enzyme cyclo-oxygenase which results in the direct inhibition of the biosynthesis of prostaglandins and thromboxanes from arachidonic acid. Aspirin also inhibits platelet aggregation.
Aspirin and other Salicylates are absorbed rapidly from the gastrointestinal tract when taken orally but absorption following rectal administration is less reliable. Aspirin and other salicylates can also be absorbed through the skin. After oral doses, absorption of non-ionised Aspirin occurs in the stomach and intestine. Some Aspirin is hydrolysed to salicylate in the gut wall. Once absorbed, Aspirin is rapidly converted to salicylate but during the first 20 minutes following oral administration, Aspirin is the predominant form of the drug in the plasma. Aspirin is 80 to 90% bound to plasma proteins and is widely distributed; its volume of distribution is reported to be 170mL/ kg body weight in adults. Both Aspirin and Salicylates have pharmacological activity although only Aspirin has an anti-platelet effect. Salicylate is extensively bound to plasma proteins and is rapidly distributed to all body parts. Salicylate appears in breast milk and crosses the placenta. Following a 325mg Aspirin dose, elimination is a first order process and the plasma-salicylate half-life is about 2 to 3 hours; at high Aspirin doses, the half-life increases to 15 to 30 hours. Salicylate is also excreted unchanged in the urine.
Cardisprin® is used as a platelet anti-aggregatory (anti-platelet) agent for the prevention of secondary myocardial infarction. It is used in patients who have suffered from unstable angina, transcient ischaemia and prevention of vascular occlusion. It reduces the risk of pulmonary embolism and deep venous thrombosis. Although Cardisprin® is formulated for cardiovascular protection, Aspirin is known for its antipyretic, analgesic and anti-inflammatory properties.
DOSAGE AND ADMINISTRATION:
Prophylaxis after heart attack or stroke: 75-150mg (one to two tablets) daily with breakfast or as directed by the physician.
For the relief of aches, pain and fever: 300-900mg every 4 -6 hours daily with food.
Not recommended for children under 12 years.