Cosmos Pharmaceutical Limited | ALBUZOL
Cosmos Limited is one of the leading manufacturers of pharmaceutical products in Kenya and East Africa. Through our specialized Human Health and Animal Health.
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ALBUZOL

CLINICAL PHARMACOLOGY:

Albendazole is a benzimidazole carbamate anthelmintic. Albendazole’s anthelmintic activity is considered to be dependent on the inhibition or destruction of cytoplasmic microtubules in the worm’s intestinal or absorptive cells. Inhibition of glucose uptake and depletion of glycogen stores follow as do other inhibitory effects leading to death of the worm within several days.

Pharmacokinetics:

Albendazole is poorly absorbed from the gastro-intestinal tract, but rapidly undergoes extensive first-pass metabolism. The principal metabolite Albendazole Sulfoxide has anthelmintic activity and a plasma half-life of about 8.5 hours. Albendazole Sulfoxide is widely distributed throughout the body including into the bile and the cerebrospinal fluid. It is approximately 70% bound to plasma protein. Albendazole Sulfoxide is eliminated in the bile; only a small amount appears to be excreted in the urine.

USES:

Albendazole is used in the treatment of cestode infections cysticercosis and echinococcosis (hydatid disease). It is also used in the treatment of single and mixed intestinal nematode infections including ascariasis, enterobiasis, hookworm, strongyloidiasis and trichuriasis.

DOSAGE AND ADMINISTRATION:

In the treatment of single or mixed intestinal nematode infection: The usual dose for adults and children aged 2 years or over with Roundworm (ascariasis), Hookworm, Pinworm (enterobiasis) and Whipworm (trichuriasis) is 400mg as a single dose. In Pinworm (enterobiasis)  the dose may be repeated in one to four weeks. In strongyloidiasis, 400mg is given once or twice daily for three consecutive days, this may be repeated after three weeks if necessary.

ALBUZOL® TABLETS

The treatment of echinococcosis: 400mg twice daily for 28 days for patients weighing over 60kg. A dose of 15mg/kg body-weight daily in two divided doses (to a maximum total daily dose of 800mg).
For cystic echinococcosis: 400mg twice daily for 28 days, then 14 days treatment free days. Repeat for 3 treatment cycles.
For alveolar echinococcosis: 400mg twice daily for 28 days  of treatment followed by 14 days without treatment may be needed to continue for months or years.
The treatment of neurocysticercosis: 400mg twice daily for patients weighing over 60kg (or 15mg per kg daily on two divided doses to a maximum total daily dose of 800mg in those weighing less than 60kg) is given for 8 to 30 days.
Giardiasis: 400mg daily for 5 days.

 

CONTRA-INDICATIONS AND  WARNINGS:

Patients receiving high doses of Albendazole such as those with echinococcosis, should be supervised closely with blood counts and liver function being monitored. If it is used in pregnancy, then such use should only be where the potential benefit justifies the risk to the foetus.
Adverse Effects: Since albendazole is poorly absorbed from the gastrointestinal tract at the usual therapeutic doses, adverse effects have generally been restricted to gastro-intestinal disturbances, such as transient abdominal pain and diarrhoea, and have tended to occur in patients being treated for heavy intestinal infection. Headache and dizzinness have been reported. Adverse effects have been reported more frequently with the high doses tried in echinococcosis and have included allergic reactions, raised liver enzyme values, alopecia, and bone marrow depression.

Overdosage: Gastric lavage may be performed in the first two to three hours after ingestion. Symptomatic treatment and general supportive measures should be undertaken as required.

Interactions: The plasma concentration of albendazole sulfoxide has been increased by praziquantel.

PHARMACEUTICAL PRECAUTIONS:

Store in a dry place below 25°C, Protect from light. Keep all medicines out of the reach of children.

LEGAL CATEGORY:
Pharmacy (P).
®Regd. TM    Ref. No.: INS140/08.09

IMAGES
  • ALBUZOL®200 Tablets (Chewable)

    Presentation
    Creamish, circular, biconvex tablet embossed 'A' on one side and a breakline on the other side. Each tablet contains: Albendazole USP 200mg.
    Pack size -2's (1x2's)

  • ALBUZOL®400 Tablets (Chewable)

    Presentation
    Creamish, biconvex, circular tablet embossed 'C' on one side and a breakline on the other side. Each tablet contains: Albendazole USP 400mg.
    Pack size - 1's, 100's (10x10's)

  • ALBUZOL®Suspension

    ALBENDAZOLE Oral Susp.USP 200mg/5ml
    Pack Size - 10mL